Re-wiring nuclear receptor-based action for enhanced therapeutic benefit

Karolien De Bosscher

Expert Scientist
VIB Group Leader, 2019-Present
Full Professor (fast-track), 2018-Present
Research Professor (BOF-ZAP), 2013-Present
Postdoctoral Fellow/Junior Group Leader: FWO-Vlaanderen, UGent (Belgium), 2002-2013
Postdoctoral Fellow: Cancer Research UK, London (UK), 2000-2002
PhD: UGent, Department Molecular and Biomedical Research, Faculty of Sciences, 2000

Research areas

Medical biotechnology Cancer Biology Human diseases Immunology & inflammation Systems biology

Research focus

Corticosteroids in the clinic are too often used with a “one-size-fits-all” rationale for the treatment/management of inflammatory diseases, metabolic disorders and lymphoid malignancies.  Glucocorticoid receptor (GR) regulation and responses are far more complex than previously recognized. GR is not a “one-size-fits-all” type of target but requires a disease-oriented approach when it comes to drug discovery especially since GR is a receptor that demonstrates a high degree of plasticity. Multiple GR conformations must therefore exist, likely resulting in different disease-specific signaling profiles. 

read more

Research topics

Publications

To showcase the world-class scientific research of the Karolien De Bosscher Lab, you can discover their scientific papers in more detail. 

more info

Jobs

We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.

more info

Team

The Karolien De Bosscher Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.

more info

Events

To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.

more info

Funding

erc    crig