Re-wiring nuclear receptor-based action for enhanced therapeutic benefit

Karolien De Bosscher

Expert Scientist
VIB Group Leader, 2019-Present
Full Professor (fast-track), 2018-Present
Research Professor (BOF-ZAP), 2013-Present
Postdoctoral Fellow/Junior Group Leader: FWO-Vlaanderen, UGent (Belgium), 2002-2013
Postdoctoral Fellow: Cancer Research UK, London (UK), 2000-2002
PhD: UGent, Department Molecular and Biomedical Research, Faculty of Sciences, 2000

Research areas

Medical biotechnology Cancer Biology Human diseases Immunology & inflammation Systems biology

Research focus

Corticosteroids in the clinic are too often used with a “one-size-fits-all” rationale for the treatment/management of inflammatory diseases, metabolic disorders and lymphoid malignancies.  Glucocorticoid receptor (GR) regulation and responses are far more complex than previously recognized. GR is not a “one-size-fits-all” type of target but requires a disease-oriented approach when it comes to drug discovery especially since GR is a receptor that demonstrates a high degree of plasticity. Multiple GR conformations must therefore exist, likely resulting in different disease-specific signaling profiles. 

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Research topics


To showcase the world-class scientific research of the Karolien De Bosscher Lab, you can discover their scientific papers in more detail. 

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We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.

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The Karolien De Bosscher Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.

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To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.

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