Re-wiring nuclear receptor-based action for enhanced therapeutic benefit
Corticosteroids in the clinic are too often used with a “one-size-fits-all” rationale for the treatment/management of inflammatory diseases, metabolic disorders and lymphoid malignancies. Glucocorticoid receptor (GR) regulation and responses are far more complex than previously recognized. GR is not a “one-size-fits-all” type of target but requires a disease-oriented approach when it comes to drug discovery especially since GR is a receptor that demonstrates a high degree of plasticity. Multiple GR conformations must therefore exist, likely resulting in different disease-specific signaling profiles.
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