Our research group develops innovative technologies to study protein-protein complexes. Moreover we pursue the implementation of genome engineering approaches in mammalian cells to push co-complex analysis at the endogenous protein level.
Several methods exist to study the association between proteins as they occur within the cell. While these methods have significantly contributed to our understanding of the so-called ‘interactome’ of the cell (the combination of all reported interactions that can occur within a cell), there are still important deficiencies in our knowledge. This is explained by the technical limitations associated with all these methods which warrants a further exploration and development of novel approaches. Our team creates and implements novel techniques to study protein complexes in human cells, with the aim to resolve challenging biological questions. We typically apply these novel strategies in collaboration with research groups around a specific biological topic or human pathology. Recent technological examples include the Virotrap platform wherein we trap protein complexes in a secreted virus-like particle so they become highly accessible for analysis; and the introduction of genome engineering to enhance BioID proximity biotinylation by implementation on the endogenous level.
To showcase the world-class scientific research of the Sven Eyckerman Lab, you can discover their scientific papers in more detail.
We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.
The Sven Eyckerman Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.