Our lab aims to develop new prevention and treatment options to control disease caused by some of the most important human respiratory viruses, including influenza virus, respiratory syncytial virus, and betacoronaviruses.

Xavier Saelens

Group Leader
Group Leader at the VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium, 2015-Present
Full Professor Molecular Virology (100%) at the Department of Biochemistry and Microbiology, Ghent University, 2020-2032
Full Professor Molecular Virology (50%) at the Department of Biochemistry and Microbiology, Ghent University, 2018-2020
Full Professor Molecular Virology (10%) at the Department of Biomedical Molecular Biology, Ghent University, 2008-2017
Expert Scientist, Inflammation Research Center, VIB, Belgium, 2009 – 2015
Project Leader, Inflammation Research Center, VIB, Belgium, 2005-2009
Postdoctoral Assistant, Faculty of Sciences, Ghent University, Belgium, 2004-2009
Postdoctoral Researcher, Cell Death Signaling unit (Peter Vandenabeele unit, UGent and VIB), 1998-2003
Postdoctoral Researcher, Lab. of Molecular Biology (Walter Fiers lab; influenza group, UGent and VIB), 1991-1997

Research areas

Human diseases Immunology & inflammation Medical biotechnology Microbiology

Research focus

Our lab has a major interest in some of the most important human respiratory viruses, including influenza A and B viruses, human respiratory syncytial virus, human parainfluenza virus 1 and 3 (hPIV1 and -3), and more recently, betacoronaviruses. Our prime aim is to develop new vaccines and nanobody-based antivirals against these viruses. A long-term aim is to develop these nanobody-based constructs as biologics that can be delivered by inhalation.

In addition, we aim to elucidate the antiviral mechanism of action of the interferon-induced mammalian virus restriction factors Mx1 and Mx2, taking advantage of interactomics tools that have been developed at the Center for Medical Biotechnology. These interactomics tools are also applied to identify and characterize interaction partners of RSV gene products. 
 

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Research topics

Publications

To showcase the world-class scientific research of the Xavier Saelens Lab, you can discover their scientific papers in more detail.

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Jobs

We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.

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Team

The Xavier Saelens Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.

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Events

To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.

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